Journal article
Genome analysis of coxsackievirus A4 isolates from hand, foot, and mouth disease cases in Shandong, China
M Wang, J Li, MX Yao, YW Zhang, T Hu, MJ Carr, S Duchêne, XC Zhang, ZJ Zhang, H Zhou, YG Tong, SJ Ding, XJ Wang, WF Shi
Frontiers in Microbiology | FRONTIERS MEDIA SA | Published : 2019
Abstract
Coxsackievirus A4 (CVA4) is one of the most prevalent pathogens associated with hand, foot and mouth disease (HFMD), an acute febrile illness in children, and is also associated with acute localized exanthema, myocarditis, hepatitis and pancreatitis. Despite this, limited CVA4 genome sequences are currently available. Herein, complete genome sequences from CVA4 strains (n = 21), isolated from patients with HFMD in Shandong province, China between 2014 and 2016, were determined and phylogenetically characterized. Phylogenetic analysis of the VP1 gene from a larger CVA4 collection (n = 175) showed that CVA4 has evolved into four separable genotypes: A, B, C, and D; and genotype D could be furt..
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Awarded by Department of Science and Technology of Shandong Province
Funding Acknowledgements
This work was supported by the National Key Technology R&D Program of China (Project No. 2017ZX10104001006), the Natural Science Foundation of Shandong Province (ZR2018PH034), the Medical and Health Science and Technology Development Projects of Shandong Province (2013WS0157 and 2017WS066), the Tai'an Municipal Science and Technology Development Program (2017NS0107), and the National Natural Science Foundation of China (81601773). W-FS was supported by the Taishan Scholars program of Shandong Province (ts201511056).