Anti-inflammatory Effects of Abdominal Vagus Nerve Stimulation on Experimental Intestinal Inflammation
Sophie C Payne, John B Furness, Owen Burns, Alicia Sedo, Tomoko Flyakumurat, Robert K Shepherd, James B Fallon
FRONTIERS IN NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2019
Electrical stimulation of the cervical vagus nerve is an emerging treatment for inflammatory bowel disease (IBD). However, side effects from cervical vagal nerve stimulation (VNS) are often reported by patients. Here we hypothesized that stimulating the vagus nerve closer to the end organ will have fewer off-target effects and will effectively reduce intestinal inflammation. Specifically, we aimed to: (i) compare off-target effects during abdominal and cervical VNS; (ii) verify that VNS levels were suprathreshold; and (iii) determine whether abdominal VNS reduces chemically-induced intestinal inflammation in rats. An electrode array was developed in-house to stimulate and record vagal neural..View full abstract
Awarded by Defense Advanced Research Projects Agency (DARPA) BTO through Space and Naval Warfare Systems Center
This work was funded by the Defense Advanced Research Projects Agency (DARPA) BTO, under the auspices of Dr. Doug Weber and Dr. Eric Van Gieson through the Space and Naval Warfare Systems Center (Contract No. N66001-15-2-4060). The Bionics Institute and the Florey Institute of Neuroscience and Mental Health acknowledge the support they receive from the Victorian Government through its Operational Infrastructural Support Program.