Rapid Assessment of Nanoparticle Extravasation in a Microfluidic Tumor Model
Mai N Vu, Pradeep Rajasekhar, Daniel P Poole, Song Yang Khor, Nghia P Truong, Cameron J Nowell, John F Quinn, Michael Whittaker, Nicholas A Veldhuis, Thomas P Davis
ACS Applied Nano Materials | AMER CHEMICAL SOC | Published : 2019
The development of nanoparticle-based targeted therapeutics for the treatment of cancer requires a well-defined understanding of the tumor microenvironment, which is challenging due to tumor complexity and heterogeneity. Recent advancements in three-dimensional (3D) cell models such as tumor-on-a-chip devices can overcome some of these challenges by providing coculture in vitro systems (tumor surrounded by tubular endothelial cells) that mimic native cellular environments to accurately study the enhanced permeability and retention (EPR) potential of drug delivery systems under flow conditions. However, inducing "leaky" vasculature in endothelial cells surrounding solid tumors in microfluidic..View full abstract
Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology
Awarded by ARC DECRA Fellowship
Awarded by ARC Australian Laureate Fellowship
We would like to thank Dr. Angus Johnston for support with data analysis and Mr. Daniel Brundel for providing materials for cell maintenance and imaging. This work was supported by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036), the Vietnamese Government and the Monash University Faculty of Pharmacy and Pharmaceutical Sciences (to M.N.V.), the Australian Government Research Training Program scholarship (to S.Y.K.), the ARC DECRA Fellowship to N.P.T. (DE180100076), Takeda Pharmaceuticals Inc. (to N.V.), and award of an ARC Australian Laureate Fellowship to T.P.D (FL140100052).