Journal article

Genome sequencing reveals coinfection by multiple chikungunya virus genotypes in a recent outbreak in Brazil

Lais Ceschini Machado, Mariana Carolina de Morais-Sobral, Tulio de Lima Campos, Mylena Ribeiro Pereira, Maria de Fatima Pessoa Militao de Albuquerque, Clement Gilbert, Rafael Freitas Oliveira Franca, Gabriel Luz Wallau

PLOS NEGLECTED TROPICAL DISEASES | PUBLIC LIBRARY SCIENCE | Published : 2019

Abstract

Chikungunya virus (CHIKV) is an RNA virus from the Togaviridae family transmitted by mosquitoes in both sylvatic and urban cycles. In humans, CHIKV infection leads to a febrile illness, denominated Chikungunya fever (CHIKF), commonly associated with more intense and debilitating outcomes. CHIKV arrived in Brazil in 2014 through two independent introductions: the Asian/Caribbean genotype entered through the North region and the African ECSA genotype was imported through the Northeast region. Following their initial introduction, both genotypes established their urban cycle among large naive human populations causing several outbreaks in the Americas. Here, we sequenced CHIKV genomes from a re..

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University of Melbourne Researchers

Grants

Awarded by Pernambuco Research Foundation (FACEPE)


Awarded by CNPq


Awarded by Agence Nationale de la Recherche


Funding Acknowledgements

This work was supported by the Pernambuco Research Foundation (FACEPE) process no APQ-0078-2.02/16 under GLW coordination and APQ-0044-2.11/16; APQ-00552.11/16 and CNPq Grant Number 439975/2016-6 under RFOF coordination. CG is supported by a grant from Agence Nationale de la Recherche (ANR-15-CE32-0011-01 TransVir). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.