A LONGITUDINAL COMPARISON OF TWO NEUROCOGNITIVE ASSESSMENT PACKAGES IN PATIENTS WITH SCHIZOPHRENIA AND HEALTHY VOLUNTEERS: TIME EFFECTS ON NEUROPSYCHOLOGICAL PERFORMANCE AND ITS RELATION TO FUNCTIONAL OUTCOME

Abstract

Cognitive impairment is a major unmet need in the treatment of schizophrenia. Over the last decade, the MATRICS Consensus Cognitive Battery (MCCB) and the cognitive-neuroscience-based Cambridge Neuropsychological Test Automated Battery (CANTAB) have been used to assess the effects of novel treatments for cognitive impairment in schizophrenia. Although both batteries purport to assess cognitive function in psychosis (Lees et al., 2017a, Keefe et al., 2013), no previous study has attempted to examine their validity longitudinally and the potential overlap between the two batteries over time. The aim of the current study was to assess the relationship between the MCCB and the CANTAB in the long..