Journal article

New molecular therapies for the treatment of hearing loss

Yutian Ma, Andrew K Wise, Robert K Shepherd, Rachael T Richardson

PHARMACOLOGY & THERAPEUTICS | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019

Abstract

An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing loss is characterized by degeneration of key structures of the sensory pathway in the cochlea such as the sensory hair cells, the primary auditory neurons and their synaptic connection to the hair cells - the ribbon synapse. Various strategies to protect or regenerate these sensory cells and structures are the subject of intensive research. Yet despite recent advances in our understandings of the capacity of the cochlea for repair and regeneration there are currently no pharmacological or biological interventions for hearing loss. Current research focusses on localized cochlear drug, gene and cell-based..

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Grants

Awarded by US Department of Defence Translation Research Award


Awarded by National Institute on Deafness and other Communication Disorders


Awarded by Action on Hearing Loss


Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by Australian National Health and Medical Research Council


Awarded by NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS


Funding Acknowledgements

This work was supported by the following funding agencies for which we are most grateful: US Department of Defence Translation Research Award (RH170019), the National Institute on Deafness and other Communication Disorders (R01DC015031), Action on Hearing Loss (G30, G39, G89), the Garnett Passe and Rodney Williams Memorial Foundation, Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036), the Robert Bulley Foundation and the Australian National Health and Medical Research Council (GNT1024350, GNT1064375, GNT1122055, and GNT1142910). The Bionics Institute acknowledges the support of the Victorian Government through its Operational Infrastructure Support Program.