Journal article

Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis

Pablo M Casillas-Espinosa, Pedro Andrade, Cesar Santana-Gomez, Tomi Paananen, Gregory Smith, Idrish Ali, Robert Ciszek, Xavier Ekolle Ndode-Ekane, Rhys D Brady, Jussi Tohka, Matthew R Hudson, Piero Perucca, Emma L Braine, Riikka Immonen, Noora Puhakka, Sandy R Shultz, Nigel C Jones, Richard J Staba, Asia Pitkanen, Terence J O'Brien

Epilepsy Research | ELSEVIER | Published : 2019

Abstract

RATIONALE: The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Centre without walls is an NIH funded multicenter consortium. One of EpiBioS4Rx projects is a preclinical post-traumatic epileptogenesis biomarker study that involves three study sites: The University of Eastern Finland, Monash University (Melbourne) and the University of California Los Angeles. Our objective is to create a platform for evaluating biomarkers and testing new antiepileptogenic treatments for post-traumatic epilepsy (PTE) using the lateral fluid percussion injury (FPI) model in rats. As only 30-50% of rats with severe lateral FPI develop PTE by 6 months post-injury, prolonged video-EEG monit..

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Grants

Awarded by National Institute of Neurological Disorders and Stroke (NINDS) Center without Walls of the National Institutes of Health (NIH)


Funding Acknowledgements

This research was supported by the National Institute of Neurological Disorders and Stroke (NINDS) Center without Walls of the National Institutes of Health (NIH) under Award Number U54NS100064 (EpiBioS4Rx).