Journal article

The Effect of Yearly-Dose Vitamin D Supplementation on Muscle Function in Mice

Alan Hayes, Emma Rybalka, Danielle A Debruin, Erik D Hanson, David Scott, Kerrie Sanders

NUTRIENTS | MDPI | Published : 2019

Abstract

Supplementation with vitamin D helps to alleviate weakness and fatigue seen with deficiency. However, large bolus doses appear to worsen the risk of falls. Whether this occurs as a direct result of muscle weakness is currently unknown. Thus, the aims of this study were to examine the muscle function following administration of high doses of vitamin D. Given the safety issues associated with bolus doses, experiments were conducted on C57BL6 mice. Mice at eight weeks of age with otherwise normal levels of vitamin D were supplemented for four weeks with a high dose (HIGH; n = 12) of vitamin D (20000 IU/kg food) designed to provide a year's worth of vitamin D. These mice were compared to another..

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