Journal article
Heart Rate Reserve in Fontan Patients: Chronotropic Incompetence or Hemodynamic Limitation?
G Claessen, A La Gerche, A Van De Bruaene, M Claeys, R Willems, S Dymarkowski, J Bogaert, P Claus, W Budts, H Heidbuchel, M Gewillig
Journal of the American Heart Association | WILEY | Published : 2019
Abstract
Background: Patients with a Fontan circulation achieve lower peak heart rates (HR) during exercise. Whether this impaired chronotropic response reflects pathology of the sinoatrial node or is a consequence of altered cardiac hemodynamics is uncertain. We evaluated the adequacy of HR acceleration throughout exercise relative to metabolic demand and cardiac output in patients with a Fontan circulation relative to healthy controls. Methods and Results: Thirty subjects (20 healthy controls and 10 Fontan patients) underwent cardiac magnetic resonance imaging with simultaneous invasive pressure recording via a pulmonary and radial artery catheter during supine bicycle exercise to near maximal exer..
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Funding Acknowledgements
This study was funded by a grant from the Fund for Scientific Research Flanders (FWO) and by The Van Itterbeek and the Eddy Merckx Research grant. Claessen is supported by a postdoctoral research grant from the Frans Van De Werf Fund for Clinical Cardiovascular Research, the UZ Leuven Future Fund, and from the Mathilde Horlait-Dapsens Scholarship. La Gerche is supported by the Fund for Scientific Research Flanders (FWO) and from the National Health and Medical Research Council (NHMRC) of Australia; Willems is supported as a postdoctoral clinical researcher by the Fund for Scientific Research Flanders (FWO).