Association of Childhood Oral Infections With Cardiovascular Risk Factors and Subclinical Atherosclerosis in Adulthood.
Pirkko J Pussinen, Susanna Paju, Jaana Koponen, Jorma SA Viikari, Leena Taittonen, Tomi Laitinen, David P Burgner, Mika Kähönen, Nina Hutri-Kähönen, Olli T Raitakari, Markus Juonala
JAMA Netw Open | Published : 2019
Importance: Severe forms of common chronic oral infections or inflammations are associated with increased cardiovascular risk in adults. To date, the role of childhood oral infections in cardiovascular risk is not known because no long-term studies have been conducted. Objective: To investigate whether signs of oral infections in childhood are associated with cardiovascular risk factors and subclinical atherosclerosis in adulthood. Design, Setting, and Participants: The cohort study (n = 755) was derived from the Cardiovascular Risk in Young Finns Study, an ongoing prospective cohort study in Finland initiated in 1980. Participants underwent clinical oral examinations during childhood, when ..View full abstract