Journal article
Prognostic Utility of a Whole-blood Androgen Receptor-based Gene Signature in Metastatic Castration-resistant Prostate Cancer
EM Kwan, H Fettke, MM Docanto, SQ To, P Bukczynska, A Mant, D Pook, N Ng, LJK Graham, S Mangiola, E Segelov, K Mahon, ID Davis, P Parente, C Pezaro, T Todenhöfer, LG Horvath, AA Azad
European Urology Focus | ELSEVIER | Published : 2021
Abstract
Background: The treatment paradigm for metastatic castration-resistant prostate cancer (mCRPC) has evolved significantly in recent years. Identifying predictive and/or prognostic biomarkers in the context of this rapidly expanding therapeutic armamentarium remains a pressing and unmet clinical need. Objective: To develop a prognostic whole-blood gene signature for mCRPC patients. Design, setting, and participants: As part of an ongoing prospective, multicentre biomarker research study (Australian Prostate Biomarker Alliance), we enrolled 115 mCRPC patients commencing chemotherapy (n = 34) or androgen receptor (AR) pathway inhibitors therapy (n = 81) and obtained pretreatment whole-blood samp..
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Funding Acknowledgements
Edmond M. Kwan: National Health and Medical Research Council (NHMRC) Postgraduate Scholarship; Sarah Q. To: NHMRC Fellowship; Ian D. Davis: NHMRC Practitioner Fellowship; Carmel Pezaro: Cancer Council Victoria Early Career Seed Grant; Lisa G. Horvath: Astellas Investigator-initiated grant; and Arun A. Azad: NHMRC project grant, Victorian Cancer Agency Clinical Research Fellowship, Astellas Investigator-initiated grant.