Journal article

Allosteric regulation of AMP-activated protein kinase by adenylate nucleotides and small-molecule drugs

Ana Laura de Souza Almeida Matos, Jonathan S Oakhill, Jose Moreira, Kim Loh, Sandra Galic, John W Scott

Biochemical Society Transactions | PORTLAND PRESS LTD | Published : 2019

Abstract

The AMP (adenosine 5'-monophosphate)-activated protein kinase (AMPK) is a key regulator of cellular and whole-body energy homeostasis that co-ordinates metabolic processes to ensure energy supply meets demand. At the cellular level, AMPK is activated by metabolic stresses that increase AMP or adenosine 5'-diphosphate (ADP) coupled with falling adenosine 5'-triphosphate (ATP) and acts to restore energy balance by choreographing a shift in metabolism in favour of energy-producing catabolic pathways while inhibiting non-essential anabolic processes. AMPK also regulates systemic energy balance and is activated by hormones and nutritional signals in the hypothalamus to control appetite and body w..

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Grants

Awarded by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior Brasil (CAPES)


Awarded by National Health and Medical Research Council


Funding Acknowledgements

A.L.d.S.A.M. was supported in part by the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior Brasil (CAPES) - Finance Code 001. J.W.S. and J.S.O. are supported by National Health and Medical Research Council project grants [1138102 and 1145265, respectively], St. Vincent's Institute of Medical Research and in part by the Victorian Government's Operational Infrastructure Support Program.