Journal article

Emerging challenges in pharmacotherapy research on attention-deficit hyperactivity disorder-outcome measures beyond symptom control and clinical trials

Ian CK Wong, Tobias Banaschewski, Jan Buitelaar, Samuele Cortese, Manfred Doepfner, Emily Simonoff, David Coghill, Phil Asherson, Paramala Santosh, Emily Smirnoff, Edmund J Sonuga-Barke, Eric Taylor, David Daley, Chris Hollis, Maite Ferrin, Ralf W Dittmann, Martin Holtmann, Aribert Rothenberger, Daniel Brandeis, Hans-Christoph Steinhausen Show all



Although pharmacological therapies are recommended as a key component in the treatment of attention-deficit hyperactivity disorder, their use continues to prompt intense debate. Despite considerable research efforts, several gaps in the knowledge base and several questions over the quality of evidence exist. Particular issues surrounding pharmacological treatments include uncertainties about long-term effectiveness and safety, safety profiles in adults, and the comparative effectiveness of different medications. In this Review, we focus on four key methodological issues for future research: (1) the use of appropriate trial designs; the need for (2) outcome measures targeting effectiveness be..

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