Are neural pathways processing airway inputs sensitized in patients with cough hypersensitivity?
Michael J Farrell, Stuart B Mazzone
PULMONARY PHARMACOLOGY & THERAPEUTICS | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2019
Patients with cough hypersensitivity exhibit unusually low thresholds for responses to tussive stimuli, exaggerated responses to suprathreshold tussive stimuli, and report spontaneous experiences of urge-to-cough in the absence of exogenous stimulation. These aberrant responses to tussive challenge have the hallmark features of behaviours associated with a sensitized sensory system. Searching for further evidence to implicate neural sensitization in the symptomatology of cough hypersensitivity warrants consideration. If up-regulation of neural circuits involved in processing of airways inputs can be demonstrated in patients with cough hypersensitivity, then strategies to reverse this dysfunc..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This work was supported by National Health and Medical Research Council of Australia, Grant ID 1078943.