Journal article

Improving medication adherence in adult kidney transplantation (IMAKT): A pilot randomised controlled trial

Jac Kee Low, Elizabeth Manias, Kimberley Crawford, Rowan Walker, William R Mulley, Nigel D Toussaint, Michael Dooley, Elaine Kennedy, Catherine L Smith, Michelle Nalder, Doris Yip, Allison Williams

SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2019

Abstract

Resources to support long-term medication adherence in kidney transplantation are limited. This study aimed to determine the efficacy of an intervention designed for kidney transplant recipients to enhance medication adherence. A single-blind, multi-site, 12-month pilot randomised controlled trial was conducted at all five public hospitals providing adult kidney transplantation in Victoria, Australia. Participants were recruited at 4 to 6 weeks post-transplantation. Thirty-five participants were randomly assigned to a 3-month intervention, involving a face-to-face meeting (a medication review and a consumer-centred video) and health coaching every two weeks. Thirty-six were randomised to rec..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC) Partnerships for Better Health grant


Funding Acknowledgements

This intervention trial was funded by an Australian National Health and Medical Research Council (NHMRC) Partnerships for Better Health grant (APP1056717). Dr. Kimberley Crawford was employed as a research fellow and her salary was partially funded by the Partnerships for Better Health grant. Jac Kee Low, a PhD researcher on this project, was partially supported by the Partnership for Better Health Grant in addition to a Faculty Graduate Research International Scholarship (FGRIS) from Monash University and a Monash Departmental Scholarship from Monash Nursing and Midwifery. Jac Kee Low was also funded by a Postgraduate Publication Award from Monash University. The authors declare that Westrock Switzerland Ltd provided free access to the medAmigo platform from December 2016 until completion of the study. Other than providing financial support, none of the sponsors were involved in the conduct of the research and data interpretation. We acknowledge the commitment and dedication of the study investigators and their clinical teams at the participating hospitals during the trial, especially Ms Dhineli Perera, Ms Kim Mullins, Ms Debbie Gregory and Ms Raylene Kwok. Additionally, we would like to thank Mr Gareth McGilvray for helping us to produce the consumer-centred video and Mr Rob ScottYoung for helping us with the concealment of group allocation.