Journal article

Postnatal inflammation following intrauterine inflammation exacerbates the development of atherosclerosis in ApoE(-/-) mice

Siroon Bekkering, Albert P Limawan, Maria U Nguyen, Lisa K Widiasmoko, Hui Lu, Salvatore Pepe, Michael M Cheung, Trevelyan R Menheniott, Megan J Wallace, David P Burgner, Timothy J Moss



Atherosclerosis is a chronic inflammatory disease that has its origins in early life. Postnatal inflammation exacerbates atherosclerosis, but the possible effect of intrauterine inflammation is largely unexplored. Exposure to inflammation in utero is common, especially in infants born preterm, who have increased cardiovascular risk in adulthood. We hypothesised that exposure to inflammation before birth would accelerate the development of atherosclerosis, with the most severe atherosclerosis following exposure to both pre- and postnatal inflammation. Here we studied the effect of prenatal and postnatal inflammation on the development of atherosclerosis by combining established techniques for..

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Awarded by National Health and Medical Research Council of Australia

Awarded by National Heart Foundation Australia

Awarded by Dutch Scientific Organisation (NWO)

Awarded by National Heart Foundation (Australia)

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia: Program [grant number 606789], Centre for Research Excellence [grant number 1057514], Research Fellowships [grant numbers 1043294 (to T.J.M.), 1064629 (to D.P.B.)]; the National Heart Foundation Australia [grant number G12M6422]; the Victorian Government's Operational Infrastructure Support Program; the Rubicon grant from the Dutch Scientific Organisation (NWO) [grant number 452173113 (to S.B.)]; the Post-graduate Biomedical Scholarship of the National Heart Foundation (Australia) [grant number PB12M6953]; and an Honorary Future Fellow of the National Heart Foundation (Australia) [grant number 100026 (to D.P.B.)].