Journal article

Emergence and divergence of major lineages of Shiga-toxin-producing Escherichia coli in Australia

Danielle J Ingle, Anders Goncalves da Silva, Mary Valcanis, Susan A Ballard, Torsten Seemann, Amy Jennison, Ivan Bastian, Rolf Wise, Martyn D Kirk, Benjamin P Howden, Deborah A Williamson



Shiga-toxin-producing Escherichia coli (STEC) infection is an important global cause of foodborne disease. To date however, genomics-based studies of STEC have been predominately focused upon STEC collected in the Northern Hemisphere. Here, we demonstrate the population structure of 485 STEC isolates in Australia, and show that several clonal groups (CGs) common to Australia were infrequently detected in a representative selection of contemporary STEC genomes from around the globe. Further, phylogenetic analysis demonstrated that lineage II of the global O157:H7 STEC was most prevalent in Australia, and was characterized by a frameshift mutation in flgF, resulting in the H-non-motile phenoty..

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Awarded by NHMRC

Awarded by European Union

Funding Acknowledgements

D. A. W. is supported by an NHMRC. Early Career Fellowship (GNT1123854) and B. P. H. is supported by an NHMRC Practitioner Fellowship (GNT1105905). Salary support for D. J. I. was supported by an NHMRC Project Grant (APP1129770) and the European Union's Horizon 2020 research and innovation programme under grant agreement 643476. The Microbiological Diagnostic Unit Public Health Laboratory is funded by the Department of Health and Human Services, Victoria.