Journal article
A systematic study towards evolutionary and epidemiological dynamics of currently predominant H5 highly pathogenic avian influenza viruses in Vietnam
LT Nguyen, SM Firestone, MA Stevenson, ND Young, LD Sims, DH Chu, TN Nguyen, L Van Nguyen, T Thanh Le, H Van Nguyen, HN Nguyen, TN Tien, TD Nguyen, BN Tran, K Matsuno, M Okamatsu, H Kida, Y Sakoda
Scientific Reports | NATURE PORTFOLIO | Published : 2019
Abstract
This study aimed to elucidate virus, host and environmental dynamics of Vietnamese H5 highly pathogenic avian influenza viruses (HPAIVs) during 2014–2017. Epidemiologically, H5 HPAIVs were frequently detected in apparently healthy domestic and Muscovy ducks and therefore these are preferred species for H5 HPAIV detection in active surveillance. Virologically, clade 2.3.2.1c and 2.3.4.4 H5 HPAIVs were predominant and exhibited distinct phylogeographic evolution. Clade 2.3.2.1c viruses clustered phylogenetically in North, Central and South regions, whilst clade 2.3.4.4 viruses only detected in North and Central regions formed small groups. These viruses underwent diverse reassortment with exis..
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Awarded by Japan Agency for Medical Research and Development
Funding Acknowledgements
We are sincerely grateful to the Vietnam DAH, especially Drs. Pham Van Dong, Nguyen Thu Thuy for their cordial support. We thank staffs of provincial Sub-DAHs and regional veterinary diagnosis centers for joining field sampling and excellent laboratory support, respectively. We also thank to Dr. Kosuke Soda (The Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University, Japan), Drs. Nguyen Thi Lan, Le Van Phan (Department of Microbiology and Infectious Disease, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Ha Noi, Vietnam) and Dr. Frank Wong (CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia) for sharing virus details and helpful suggestions. This study was financially supported by Program for Leading Graduate Schools (F01) from Japan Society for the Promotion of Science (JSPS) and the Japan Initiative for Global Research Network on Infectious Diseases (J-GRID) from AMED (JP18fm0108008). S.M.F. is supported by an Australian Research Council Discovery Early Career Researcher Award (DE160100477). N.D.Y. holds a Career Development Fellowship funded from National Health and Medical Research Council (NHMRC) of Australia.