Intra-individual comparison of Ga-68-PSMA-11 and F-18-DCFPyL normal-organ biodistribution
Goncalo Ferreira, Amir Iravani, Michael S Hofman, Rodney J Hicks
CANCER IMAGING | BMC | Published : 2019
PURPOSE: Detailed data comparing the biodistribution of PSMA radioligands is still scarce, raising concerns regarding the comparability of different compounds. We investigated differences in normal-organ biodistribution and uptake variability between the two most commonly PSMA tracers in clinical use, 68Ga-PSMA-11 and 18F-DCFPyL. METHODS: This retrospective analysis included 34 patients with low tumor burden referred for PET/CT imaging with 68Ga-PSMA-11 and subsequently 18F-DCFPyL. Images were acquired with 4 cross-calibrated PET/CT systems. Volumes of interest were placed on major salivary and lacrimal glands, liver, spleen, duodenum, kidneys, bladder, blood-pool and muscle. Normal-organ bi..View full abstract
Michael S. Hofman is supported by a Clinical Fellowship Award from the Peter MacCallum Foundation. Rodney J. Hicks is supported by a National Health and Medical Research Council Practitioner Fellowship.