Journal article

CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3( ) regulatory T cells

Antonia Polichen, Keisuke Horikawa, Liz Milla, Jennifer Kofler, Philippe Bouillet, Gabrielle T Belz, Lorraine A O'Reilly, Christopher C Goodnow, Andreas Strasser, Daniel HD Gray

Immunology & Cell Biology | WILEY | Published : 2019

Abstract

FOXP3+ regulatory T (Treg) cells are essential for immunological tolerance and immune homeostasis. Despite a great deal of interest in modulating their number and function for the treatment of autoimmune disease or cancer, the precise mechanisms that control the homeostasis of Treg cells remain unclear. We report a new ENU-induced mutant mouse, lack of costimulation (loco), with atopic dermatitis and Treg cell deficiency typical of Card11 loss-of-function mutants. Three distinct single nucleotide variants were found in the Card11 introns 2, 10 and 20 that cause the loss of CARD11 expression in these mutant mice. These mutations caused the loss of thymic-derived, Neuropilin-1+ (NRP1+ ) Treg c..

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