Journal article

Personality disorder and functioning in major depressive disorder: a nested study within a randomized controlled trial

Bianca E Kavanagh, Lana J Williams, Michael Berk, Alyna Turner, Henry J Jackson, Mohammadreza Mohebbi, Buranee Kanchanatawan, Melanie M Ashton, Chee H Ng, Michael Maes, Lesley Berk, Gin S Malhi, Nathan Dowling, Ajeet B Singh, Olivia M Dean

BRAZILIAN JOURNAL OF PSYCHIATRY | ASSOC BRASILEIRA PSIQUIATRIA | Published : 2020

Abstract

OBJECTIVE: This study aimed to determine if personality disorder (PD) predicted functional outcomes in patients with major depressive disorder (MDD). METHODS: Data (n=71) from a double-blind, randomized, placebo-controlled 12-week trial assessing the efficacy of 200 mg/day adjunctive minocycline for MDD were examined. PD was measured using the Standardized Assessment of Personality Abbreviated Scale. Outcome measures included Clinical Global Impression - Improvement (CGI-I), Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Social and Occupational Functioning Scale (SOFAS), and Range of Impaired Functioning (RIFT). Analysis of covariance was used to examine the impact of PD..

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