Journal article
Personality disorder and functioning in major depressive disorder: a nested study within a randomized controlled trial
Bianca E Kavanagh, Lana J Williams, Michael Berk, Alyna Turner, Henry J Jackson, Mohammadreza Mohebbi, Buranee Kanchanatawan, Melanie M Ashton, Chee H Ng, Michael Maes, Lesley Berk, Gin S Malhi, Nathan Dowling, Ajeet B Singh, Olivia M Dean
BRAZILIAN JOURNAL OF PSYCHIATRY | ASSOC BRASILEIRA PSIQUIATRIA | Published : 2020
Abstract
OBJECTIVE: This study aimed to determine if personality disorder (PD) predicted functional outcomes in patients with major depressive disorder (MDD). METHODS: Data (n=71) from a double-blind, randomized, placebo-controlled 12-week trial assessing the efficacy of 200 mg/day adjunctive minocycline for MDD were examined. PD was measured using the Standardized Assessment of Personality Abbreviated Scale. Outcome measures included Clinical Global Impression - Improvement (CGI-I), Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Social and Occupational Functioning Scale (SOFAS), and Range of Impaired Functioning (RIFT). Analysis of covariance was used to examine the impact of PD..
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Funding Acknowledgements
The authors would like to acknowledge the support of the Brain and Behavior Foundation and the Australasian Society for Bipolar and Depressive Disorders (ASBDD) (in collaboration with Servier). This manuscript is a contraction of a thesis for BEK's Doctor of Philosophy program at Deakin University.T