Journal article

Associations of pigmentary and naevus phenotype with melanoma risk in two populations with comparable ancestry but contrasting levels of ambient sun exposure

AE Cust, M Drummond, DT Bishop, L Azizi, H Schmid, MA Jenkins, JL Hopper, BK Armstrong, JF Aitken, RF Kefford, GG Giles, F Demenais, AM Goldstein, JH Barrett, PA Kanetsky, DE Elder, GJ Mann, JA Newton-Bishop

Journal of the European Academy of Dermatology and Venereology | WILEY | Published : 2019


BACKGROUND: People at high risk of developing melanoma are usually identified by pigmentary and naevus phenotypes. OBJECTIVE: We examined whether associations of these phenotypes with melanoma risk differed by ambient sun exposure or participant characteristics in two population-based, case-control studies with comparable ancestry but different ambient sun exposure. METHODS: Data were analysed from 616 cases and 496 controls from the Australian Melanoma Family Study and 2012 cases and 504 controls from the Leeds (UK) case-control study. Questionnaire, interview and dermatological skin examination data were collected using the same measurement protocols. Relative risks were estimated as odds ..

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