Journal article

Long-read sequencing reveals a 4.4kb tandem repeat region in the mitogenome of Echinococcus granulosus (sensu stricto) genotype G1

Liina Kinkar, Pasi K Korhonen, Huimin Cai, Charles G Gauci, Marshall W Lightowlers, Urmas Saarma, David J Jenkins, Jiandong Li, Junhua Li, Neil D Young, Robin B Gasser

PARASITES & VECTORS | BMC | Published : 2019


BACKGROUND: Echinococcus tapeworms cause a severe helminthic zoonosis called echinococcosis. The genus comprises various species and genotypes, of which E. granulosus (sensu stricto) represents a significant global public health and socioeconomic burden. Mitochondrial (mt) genomes have provided useful genetic markers to explore the nature and extent of genetic diversity within Echinococcus and have underpinned phylogenetic and population structure analyses of this genus. Our recent work indicated a sequence gap (> 1 kb) in the mt genomes of E. granulosus genotype G1, which could not be determined by PCR-based Sanger sequencing. The aim of the present study was to define the complete mt genom..

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