Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3
Suzanne Hosie, Melina Ellis, Mathusi Swaminathan, Fatima Ramalhosa, Gracia O Seger, Gayathri K Balasuriya, Christopher Gillberg, Maria Rastam, Leonid Churilov, Sonja J McKeown, Nalzi Yalcinkaya, Petri Urvil, Tor Savidge, Carolyn A Bell, Oonagh Bodin, Jen Wood, Ashley E Franks, Joel C Bornstein, Elisa L Hill-Yardin
Autism Research | WILEY | Published : 2019
Awarded by United States Department of Defense's Congressionally Directed Medical Research Programs (CDMRP) Autism Research Program
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by ARC Future Fellowship
Awarded by National Institute of Allergy and Infectious Diseases
This work was supported by an Idea Development Award from the United States Department of Defense's Congressionally Directed Medical Research Programs (CDMRP) Autism Research Program (AR110134) to E.L.H.-Y. and J.C.B.; the Victorian Government through the Operational Infrastructure Scheme, National Health and Medical Research Council (NHMRC) project grants (APP566642 to J.C.B. and APP1047674 to E.L.H.-Y.) and the Royal Melbourne Hospital Neuroscience Foundation. E.L.H.-Y. also received an ARC Future Fellowship (FT160100126) and an RMIT Vice Chancellor's Senior Research Fellowship which supported G.K.B. and S.H. T.S., P.U., and N.Y. were funded by grants RO1AI100914, P30-DK56338, and U01-AI24290 awards to Baylor College of Medicine funded from the National Institute of Allergy and Infectious Diseases and National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health (T.C.S.). The Hu antibody was a gift from Dr. V. Lennon, Mayo Clinic, USA. The authors thank Laura Parry for gene expression experimental design, M. Mohsenipour for genotyping, Candice Fung for primer design, Athena Latina for microbial sampling, M. Kesar, B. McInnes, T. Drever, M. Williams, and S. Taverner for animal care and E. Mayer, A. Moulden, and R. Savarirayan for their constructive comments on this manuscript.