E6AP goes viral: the role of E6AP in viral- and non-viral-related cancers
Ivona Bandilovska, Simon P Keam, Cristina Gamell, Claudia Machicado, Sue Haupt, Ygal Haupt
Carcinogenesis | OXFORD UNIV PRESS | Published : 2019
Since its discovery, the E3 ubiquitin ligase E6-associated protein (E6AP) has been studied extensively in two pathological contexts: infection by the human papillomavirus (HPV), and the neurodevelopmental disorder, Angelman syndrome. Vital biological links between E6AP and other viruses, namely hepatitis C virus and encephalomyocarditis virus, have been recently uncovered. Critically, oncogenic E6AP activities have been demonstrated to contribute to cancers of both viral and non-viral origins. HPV-associated cancers serve as the primary example of E6AP involvement in cancers driven by viruses. Studies over the past few years have exposed a role for E6AP in non-viral-related cancers. This has..View full abstract
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