Journal article

Polycomb repressive complex 2 is a critics mediator of allergic inflammation

Christine R Keenan, Nadia Iannarella, Alexandra L Garnham, Alexandra C Brown, Richard Y Kim, Jay C Horvat, Philip M Hansbro, Stephen L Nutt, Rhys S Allan



Awarded by National Health and Medical Research Council of Australia

Awarded by Australian Research Council

Funding Acknowledgements

We thank Florence Cammas (IRCM, France) for the Cbx1, Cbx3, and Trim28<SUP>fl/fl</SUP> mice, Alexander Tarakhovsky (Rockefeller University) for the Ezh2<SUP>fl/fl</SUP> mice, and Stuart Orkin (Dana-Farber Cancer Institute, Harvard) for the Eed<SUP>fl/fl</SUP> mice. We also thank James Moon (Massachusetts General Hospital) for providing class II OVA-MHC tetramers (OVA-2C, OVA-3C). Assessment of total and OVA-specific IgE was generously performed by Kristy O'Donnell in the laboratory of David Tarlinton (Monash University). This work was supported by grants and fellowships from the National Health and Medical Research Council of Australia (1125436 to CRK, 1100451 to RSA, and 1058238 and 1054925 to SLN), the Australian Research Council (130100541 to RSA), and an American Asthma Foundation Grant (to SLN and RSA). This study was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support scheme and the Australian Cancer Research Fund.