Journal article

Importance of All and AT2 receptors in the nucleus of the solitary tract in cardiovascular responses induced by a high-fat diet

Guilherme F Speretta, Prashant J Ruchaya, Maria A Delbin, Mariana R Melo, Hongwei Li, Jose Menani, Colin Sumners, Eduardo Colombari, Mirian Bass, Debora SA Colombari

Hypertension Research | NATURE PUBLISHING GROUP | Published : 2019

Abstract

A high-fat diet (HFD) induces an increase in arterial pressure and a decrease in baroreflex function, which may be associated with increased expression of angiotensin type 1 receptor (AT1R) and pro-inflammatory cytokine genes and reduced expression of the angiotensin type 2 receptor (AT2R) gene within the nucleus of the solitary tract (NTS), a key area of the brainstem involved in cardiovascular control. Thus, in the present study, we evaluated the changes in arterial pressure and gene expression of components of the renin-angiotensin system (RAS) and neuroinflammatory markers in the NTS of rats fed a HFD and treated with either an AT1R blocker or with virus-mediated AT2R overexpression in t..

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Grants

Awarded by Fundacao de Amparo a Pesquisa do Estado de Sao Paulo


Awarded by Conselho Nacional de Desenvolvimento Cientifico e Tecnologico


Awarded by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior


Awarded by NIH


Funding Acknowledgements

The authors thank Dr. Rodrigo Tomeo and Dr. Regina C. Vendramini for providing expert technical assistance, Silvana A. D. Malavolta and Carla D. Alencar for providing secretarial assistance and Ana V. Oliveira for providing animal care. This study was supported by Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2013/13118-0; 2015/234677]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [304873/2014-4; 425586/2016-2; 308099/2017-6]; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior [33001014037P4 and Finance Code 001]; and NIH grant HL-07803.