Journal article

Right sizing for vaccine effectiveness studies: how many is enough for reliable estimation?

Olivia H Price, Kylie S Carville, Sheena G Sullivan

COMMUNICABLE DISEASES INTELLIGENCE | AUSTRALIAN GOVERNMENT, DEPT HEALTH & AGEING | Published : 2019

Abstract

Background: The precision of vaccine effectiveness (VE) estimates is dependent on sample size and sampling methods. In Victoria, participating general practitioners (GPs) are not limited by the number of influenza-like illness (ILI) patients they collect respiratory samples (swabs) from in sentinel surveillance. However, in the context of scarce resources it is of interest to determine the minimum sample size needed for reliable estimates. Methods: Following the test-negative design, patients with ILI were recruited by GPs and tested for influenza. Descriptive analyses were conducted to assess possible selection bias introduced by GPs. VE was calculated by logistic regression as [1 – odds ra..

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