hicap: In Silico Serotyping of the Haemophilus influenzae Capsule Locus
Stephen C Watts, Kathryn E Holt
Journal of Clinical Microbiology | AMER SOC MICROBIOLOGY | Published : 2019
Haemophilus influenzae exclusively colonizes the human nasopharynx and can cause a variety of respiratory infections as well as invasive diseases, including meningitis and sepsis. A key virulence determinant of H. influenzae is the polysaccharide capsule, of which six serotypes are known, each encoded by a distinct variation of the capsule biosynthesis locus (cap-a to cap-f). H. influenzae type b (Hib) was historically responsible for the majority of invasive H. influenzae disease, and its prevalence has been markedly reduced in countries that have implemented vaccination programs targeting this serotype. In the postvaccine era, nontypeable H. influenzae emerged as the most dominant group ca..View full abstract
This work was supported by the Bill & Melinda Gates Foundation, Seattle, WA, and the by Australian Government Research Training Program. K.E.H. is supported by a Senior Medical Research Fellowship from the Viertel Foundation of Victoria.