Journal article

hicap: In Silico Serotyping of the Haemophilus influenzae Capsule Locus

Stephen C Watts, Kathryn E Holt

Journal of Clinical Microbiology | AMER SOC MICROBIOLOGY | Published : 2019


Haemophilus influenzae exclusively colonizes the human nasopharynx and can cause a variety of respiratory infections as well as invasive diseases, including meningitis and sepsis. A key virulence determinant of H. influenzae is the polysaccharide capsule, of which six serotypes are known, each encoded by a distinct variation of the capsule biosynthesis locus (cap-a to cap-f). H. influenzae type b (Hib) was historically responsible for the majority of invasive H. influenzae disease, and its prevalence has been markedly reduced in countries that have implemented vaccination programs targeting this serotype. In the postvaccine era, nontypeable H. influenzae emerged as the most dominant group ca..

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University of Melbourne Researchers