Smoking, Alcohol, and Biliary Tract Cancer Risk: A Pooling Project of 26 Prospective Studies

EE McGee; SS Jackson; JL Petrick; AL Van Dyke; HO Adami; D Albanes; G Andreotti; LE Beane-Freeman; AB de Gonzalez; JE Buring; AT Chan; Y Chen; GE Fraser; ND Freedman; YT Gao; SM Gapstur; JM Gaziano; GG Giles; EJ Grant; F Grodstein; P Hartge; M Jenab; CM Kitahara; SF Knutsen; WP Koh; SC Larsson; IM Lee; LM Liao; J Luo; RL Milne; KR Monroe; ML Neuhouser; KM O’Brien; U Peters; JN Poynter; MP Purdue; K Robien; DP Sandler; N Sawada; C Schairer; HD Sesso; TG Simon; R Sinha; R Stolzenberg-Solomon; S Tsugane; R Wang; E Weiderpass; SJ Weinstein; E White; A Wolk; JM Yuan; A Zeleniuch-Jacquotte; X Zhang; B Zhu; KA McGlynn; PT Campbell; J Koshiol

Journal article

Smoking, Alcohol, and Biliary Tract Cancer Risk: A Pooling Project of 26 Prospective Studies

EE McGee, SS Jackson, JL Petrick, AL Van Dyke, HO Adami, D Albanes, G Andreotti, LE Beane-Freeman, AB de Gonzalez, JE Buring, AT Chan, Y Chen, GE Fraser, ND Freedman, YT Gao, SM Gapstur, JM Gaziano, GG Giles, EJ Grant, F Grodstein Show all

Journal of the National Cancer Institute | OXFORD UNIV PRESS INC | Published : 2019

DOI: 10.1093/JNCI/DJZ103

Abstract

Background: Tobacco and alcohol are well-established risk factors for numerous cancers, yet their relationship to biliary tract cancers remains unclear. Methods: We pooled data from 26 prospective studies to evaluate associations of cigarette smoking and alcohol consumption with biliary tract cancer risk. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for associations with smoking and alcohol consumption were calculated. Random-effects meta-analysis produced summary estimates. All statistical tests were two-sided. Results: Over a period of 38 369 156 person-years of follow-up, 1391 gallbladder, 758 intrahepatic bile duct, 1208 extrahepatic bile duct, and 623 ampulla of..

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