The Natural Cytotoxicity Receptors in Health and Disease
Alexander David Barrow, Claudia Jane Martin, Marco Colonna
FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2019
The Natural Cytotoxicity Receptors (NCRs), NKp46, NKp44, and NKp30, were some of the first human activating Natural Killer (NK) cell receptors involved in the non-MHC-restricted recognition of tumor cells to be cloned over 20 years ago. Since this time many host- and pathogen-encoded ligands have been proposed to bind the NCRs and regulate the cytotoxic and cytokine-secreting functions of tissue NK cells. This diverse set of NCR ligands can manifest on the surface of tumor or virus-infected cells or can be secreted extracellularly, suggesting a remarkable NCR polyfunctionality that regulates the activity of NK cells in different tissue compartments during steady state or inflammation. Moreov..View full abstract
CM was the recipient of a Susan Keyes-Pearce Microbiology and Immunology laboratory experience award.