Journal article

Functional genomics reveals extensive diversity in Staphylococcus epidermidis restriction modification systems compared to Staphylococcus aureus

Jean YH Lee, Glen Carter, Sacha Pidot, Romain Guérillot, Torsten Seemann, Anders Gonçalves da Silva, Timothy Foster, Benjamin Howden, Timothy Stinear, Ian Monk

Published : 2019


Staphylococcus epidermidis is a significant opportunistic pathogen of humans. Molecular studies in this species have been hampered by the presence of restriction-modification (RM) systems that limit introduction of foreign DNA. Here we establish the complete genomes and methylomes for seven clinically significant, genetically diverse S. epidermidis isolates and perform the first systematic genomic analyses of the type I RM systems within both S. epidermidis and Staphylococcus aureus . Our analyses revealed marked differences in the gene arrangement, chromosomal location and movement of type I RM systems between the two species. Unlike S. aureus , S. epidermidis type I RM systems demonstrate ..

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