Journal article

Brain Magnetic Resonance Imaging Findings in Children after Antenatal Maternal Depression Treatment, a Longitudinal Study Built on a Pilot Randomized Controlled Trial

Laura S Bleker, Jeannette Milgrom, Donna Parker, Alan W Gemmill, Christopher J Holt, Alan Connelly, Huibert Burger, Tessa J Roseboom, Susanne R de Rooij

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | MDPI | Published : 2019

Abstract

Antenatal depression is associated with an increased risk of offspring neuro-developmental disorders, potentially as a consequence of an altered brain development in utero. We hypothesized that reducing maternal depression by Cognitive Behavioral Therapy (CBT) during pregnancy may ameliorate the offspring's brain (micro)structural outcomes. 54 pregnant women with a diagnosed clinical depression were randomly allocated to CBT or Treatment as Usual (TAU), showing moderate to large depression symptom improvements after CBT. In 16 of their children (69% boys, N(TAU) = 8, N(CBT) = 8, mean age = 5.9 years, range = 3.9-7.1 years) brain Magnetic Resonance Imaging (MRI) scans were conducted. Children..

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Grants

Awarded by Brain and Behavior Research foundation (NARSAD Young Investigator Grant)


Awarded by DynaHealth: Understanding the Dynamic determinants of glucose homeostasis and psychological capacity to promote healthy and active ageing


Funding Acknowledgements

This study was funded by the Brain and Behavior Research foundation (NARSAD Young Investigator Grant, project 22975). The first author is funded by DynaHealth: Understanding the Dynamic determinants of glucose homeostasis and psychological capacity to promote healthy and active ageing under Grant Agreement no 633595 (Horizon2020). The funding organizations had no role in the design and conduct of the study; collection, management, and analysis of data; or preparation, review and approval of the manuscript.