Quantile regression analysis reveals widespread evidence for gene-environment or gene-gene interactions in myopia development
Alfred Pozarickij, Cathy Williams, Pirro G Hysi, Jeremy A Guggenheim, Tariq Aslam, Sarah A Barman, Jenny H Barrett, Paul Bishop, Peter Blows, Catey Bunce, Roxana O Carare, Usha Chakravarthy, Michelle Chan, Sharon YL Chua, David P Crabb, Philippa M Cumberland, Alexander Day, Parul Desai, Bal Dhillon, Andrew D Dick Show all
Communications Biology | NATURE PUBLISHING GROUP | Published : 2019
Awarded by National Eye Research Centre grant
Awarded by NIHR Senior Research Fellowship
Awarded by Department for Health - NIHR
Awarded by Special Trustees of Moorfields Eye Hospital, London, United Kingdom
This research has been conducted using the UK Biobank Resource (applications #17351). We thank Arkan Abadi and David Meyre (McMaster University) for advice on R codes. The work was funded by the National Eye Research Centre grant SAC015 (JAG, CW), and an NIHR Senior Research Fellowship award SRF-2015-08-005 (CW). UK Biobank was established by the Wellcome Trust; the UK Medical Research Council; the Department for Health (London, UK); Scottish Government (Edinburgh, UK); and the Northwest Regional Development Agency (Warrington, UK). It also received funding from the Welsh Assembly Government (Cardiff, UK); the British Heart Foundation; and Diabetes UK. Collection of eye and vision data was supported by The Department for Health through an award made by the NIHR to the Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, and UCL Institute of Ophthalmology, London, United Kingdom (grant no. BRC2_009). Additional support was provided by The Special Trustees of Moorfields Eye Hospital, London, United Kingdom (grant no. ST 12 09). Data analysis was carried out using the RAVEN computing cluster, maintained by the ARCCA group at Cardiff University ARCCA and the BLUE CRYSTAL3 computing cluster maintained by the HPC group at the University of Bristol.