Journal article
Intermittent screening and treatment with dihydroartemisinin-piperaquine and intermittent preventive therapy with sulfadoxine-pyrimethamine have similar effects on malaria antibody in pregnant Malawian women
A Teo, LM Randall, M Madanitsa, V Mwapasa, LK Phiri, C Khairallah, C Buffet, A Karahalios, DL Narum, FOT Kuile, SJ Rogerson
Scientific Reports | NATURE PORTFOLIO | Published : 2019
Abstract
In a randomised trial comparing intermittent screening and treatment (IST) with dihydroartemisinin-piperaquine (DP) and intermittent preventive therapy against malaria in pregnancy (IPT) with sulfadoxine-pyrimethamine (SP) in Malawi, the impacts of IST-DP and IPT-SP on the development and maintenance of malaria antibody immunity were compared. Pregnant Malawian women were randomised to receive IST-DP or IPT-SP. In a nested study, paired enrolment and delivery plasma samples from 681 women were assayed for antibodies against recombinant antigens and for IgG and opsonising antibodies to antigens found on infected erythrocytes (IEs). At delivery, antibody responses did not differ between study ..
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Awarded by Bill and Melinda Gates Foundation
Funding Acknowledgements
We thank the pregnant women for their participation in the study. We are grateful to Prof James Beeson and Christine Langer for providing merozoite antigens, MSP 3 and PfRh2, Prof Robin Anders for merozoite antigen, MSP2 and Dr. Joseph Smith for DBL5. We thank Prof Graham Brown for input into the study design and interpretation. This study was supported by National Health and Medical Research council of Australia awarded to SJR and Graham Brown, Grant Number: 10244441. The parent trial was supported by the European and Developing Countries Clinical Trial Partnership, Grant Number: IP.2007.31080.003. Sample collection was supported in part by Malaria in Pregnancy Consortium, which receives funding from the Bill & Melinda Gates Foundation, Grant Number: 46099. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.