Journal article
World Workshop on Oral Medicine VII: Prognostic biomarkers in oral leukoplakia: A systematic review of longitudinal studies
A Villa, A Celentano, I Glurich, WS Borgnakke, SB Jensen, DE Peterson, K Delli, D Ojeda, A Vissink, CS Farah
Oral Diseases | WILEY | Published : 2019
DOI: 10.1111/odi.13087
Abstract
Objective: To identify the prognostic biomarker candidates for stratification and long-term surveillance of oral leukoplakia progressing to cancer via a systematic literature review. Materials and Methods: Systematic searches with no date restrictions were conducted on March 29, 2018, targeting the databases PubMed (Ovid), EMBASE (Ovid), EBM (Ovid), and Web of Science (ISI). Bias was assessed using the Quality in Prognosis Studies tool. Biomarkers were stratified based on hallmarks of cancer. Results: Inclusion criteria were met by 25 of 3,415 studies. A range of biomarkers were evaluated experimentally for risk stratification, prognosis, and surveillance of oral leukoplakia in tissue, blood..
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Awarded by National Institutes of Health
Funding Acknowledgements
American Academy of Oral Medicine; European Association of Oral Medicine; The British Society for Oral Medicine; The National Institute of Dental and Craniofacial Research; Colgate-Palmolive; Henry Schein Cares Foundation; AFYX; Unilever; Xerostom; Oral Diseases; The World Dental Education Foundation