Journal article

World Workshop on Oral Medicine VII: Prognostic biomarkers in oral leukoplakia: A systematic review of longitudinal studies

Alessandro Villa, Antonio Celentano, Ingrid Glurich, Wenche S Borgnakke, Siri Beier Jensen, Douglas E Peterson, Konstantina Delli, David Ojeda, Arjan Vissink, Camile S Farah

Oral Diseases | WILEY | Published : 2019

Abstract

OBJECTIVE: To identify the prognostic biomarker candidates for stratification and long-term surveillance of oral leukoplakia progressing to cancer via a systematic literature review. MATERIALS AND METHODS: Systematic searches with no date restrictions were conducted on March 29, 2018, targeting the databases PubMed (Ovid), EMBASE (Ovid), EBM (Ovid), and Web of Science (ISI). Bias was assessed using the Quality in Prognosis Studies tool. Biomarkers were stratified based on hallmarks of cancer. RESULTS: Inclusion criteria were met by 25 of 3,415 studies. A range of biomarkers were evaluated experimentally for risk stratification, prognosis, and surveillance of oral leukoplakia in tissue, blood..

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University of Melbourne Researchers

Grants

Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Funding Acknowledgements

American Academy of Oral Medicine; European Association of Oral Medicine; The British Society for Oral Medicine; The National Institute of Dental and Craniofacial Research; Colgate-Palmolive; Henry Schein Cares Foundation; AFYX; Unilever; Xerostom; Oral Diseases; The World Dental Education Foundation