Journal article

Telomere Length and Vascular Phenotypes in a Population-Based Cohort of Children and Midlife Adults

Thien Nguyen Minh, Regan Vryer, Sarath Ranganathan, Kate Lycett, Anneke Grobler, Terence Dwyer, Markus Juonala, Richard Saffery, David Burgner, Melissa Wake

Journal of the American Heart Association | WILEY | Published : 2019

Abstract

Background Telomere length has been inversely associated with cardiovascular disease in adulthood, but its relationship to preclinical cardiovascular phenotypes across the life course remains unclear. We investigated associations of telomere length with vascular structure and function in children and midlife adults. Methods and Results Population-based cross-sectional CheckPoint (Child Health CheckPoint) study of 11- to 12-year-old children and their parents, nested within the LSAC (Longitudinal Study of Australian Children). Telomere length (telomeric genomic DNA [T]/β-globin single-copy gene [S] [T/S ratio]) was measured by quantitative polymerase chain reaction from blood-derived genomic ..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by Royal Children's Hospital Foundation


Awarded by National Heart Foundation of Australia


Awarded by Financial Markets Foundation for Children


Awarded by NHMRC Postgraduate Scholarship


Awarded by NHMRC Senior Research Fellowship


Awarded by NHMRC Early Career Fellowship


Awarded by National Heart Foundation Postdoctoral Fellowship


Awarded by NHMRC Fellowship


Awarded by Honorary Future Leader Fellowship of the National Heart Foundation of Australia


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (Project Grants 1041352 and 1109355), The Royal Children's Hospital Foundation (2014-241), the Murdoch Children's Research Institute (MCRI), The University of Melbourne, the National Heart Foundation of Australia (100660), and Financial Markets Foundation for Children (2014-055 and 2016-310). The MCRI administered the grants for the study and provided infrastructural support (information technology and biospecimen management), but played no role in the conduct or analysis of the trial. Research at the MCRI is supported by the Victorian Government's Operational Infrastructure Support Program. Nguyen was supported by an NHMRC Postgraduate Scholarship (1115167). Saffery was supported by an NHMRC Senior Research Fellowship (1045161). Ranganathan was supported by an MCRI Clinician Scientist Award. Lycett was supported by an NHMRC Early Career Fellowship (1091124) and a National Heart Foundation Postdoctoral Fellowship (101239). Grobler and Dwyer reported no sources of funding. Juonala was supported by the Federal Research Grant of Finland to Turku University Hospital and the Juho Vainio Foundation. Burgner was supported by an NHMRC Fellowship (1064629) and an Honorary Future Leader Fellowship of the National Heart Foundation of Australia (100369). Wake was supported by an NHMRC Senior Research Fellowship (1046518) and Cure Kids New Zealand. The funding bodies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.