Sleep regularity is associated with sleep-wake and circadian timing, and mediates daytime function in Delayed Sleep-Wake Phase Disorder
Jade M Murray, Andrew JK Phillips, Michelle Magee, Tracey L Sletten, Christopher Gordon, Nicole Lovato, Bei Bei, Delwyn J Bartlett, David J Kennaway, Leon C Lack, Ronald R Grunstein, Steven W Lockley, Shantha MW Rajaratnam, E Armstrong, K Chohan, Y Djavadkhani, K Dodds, S Gunaratnam, M Hardy, S Joosten Show all
SLEEP MEDICINE | ELSEVIER SCIENCE BV | Published : 2019
BACKGROUND: In healthy populations, irregular sleep patterns are associated with delayed sleep and poor functional/mood outcomes. Currently, it is unknown whether irregular sleep contributes to poor functional/mood outcomes in individuals with Delayed Sleep-Wake Phase Disorder (DSWPD). METHODS: In 170 patients with DSWPD, we collected sleep-wake patterns, dim light melatonin onset (DLMO), and functional/mood outcomes. The Sleep Regularity Index (SRI) and other sleep timing metrics were computed. Correlations of SRI were computed with phase angle (difference between DLMO and desired bedtime), sleep timing and quality variables, daytime function, sleep-related daytime impairment, mood, and ins..View full abstract
The study was funded by a research grant from the National Health and Medical Research Council (NHMRC) to SMWR, SWL, RRG, LCL, DJK, and research support from Philips Respironics and the NHMRC Australasian Sleep Trials Network. JMM was supported by an Australian Postgraduate Award from Monash University and PhD top-up scholarship from the Cooperative Research Centre for Alertness, Safety and Productivity. BB was supported by a NHMRC fellowship. RRG is supported by a NHMRC Senior Principal Research Fellowship.