Increased neuropeptide Y pressor activity in Goldblatt hypertensive rats: In vivo studies with BIBP 3226

Abstract

Nanomoles of neuropeptide Y (NPY) and noradrenaline (NA), administered IV to pentobarbital-anesthetized rats, caused nearly equipotent dose- dependent pressor responses in normotensive rats. However, in renovascular Goldblatt hypertensive rats, the dose-response curves for both NPY and NA were significantly displaced to the left, approximately threefold. Intravenous administration of BIBP 3226 (30-180 μg/kg) did not consistently lower blood pressure, per se, but did evoke competitive antagonism of the NPY pressor response in both rat populations. The magnitude of the NPY antagonism evoked by BIBP 3226 was comparable in normotensive and hypertensive rats. The absence of NA antagonism demonstr..