Journal article
Discussion of some ‘knowns’ and some ‘unknowns’ about the tumour suppressor p53
E Lieschke, Z Wang, GL Kelly, A Strasser
Journal of Molecular Cell Biology | OXFORD UNIV PRESS | Published : 2019
DOI: 10.1093/jmcb/mjy077
Abstract
Activation of the tumour suppressor p53 upon cellular stress can induce a number of different cellular processes. The diverse actions of these processes are critical for the protective function of p53 in preventing the development of cancer. However, it is still not fully understood which process(es) activated by p53 is/are critical for tumour suppression and how this might differ depending on the type of cells undergoing neoplastic transformation and the nature of the drivers of oncogenesis. Moreover, it is not clear why upon activation of p53 some cells undergo cell cycle arrest and senescence whereas others die by apoptosis. Here we discuss some of the cellular processes that are crucial ..
View full abstractGrants
Awarded by Leukemia and Lymphoma Society
Funding Acknowledgements
Work in the authors' laboratories is supported by the National Health and Medical Research Council, Australia (Program Grant 1113133; Fellowship 1116937; Project grants 1086291 and 1143105), The Leukemia and Lymphoma Society (Specialised Center of Research, SCOR 7015-18), The Cancer Council Victoria (Venture Grant and Grants in Aid 1102104 and 1147328), The Leukaemia Foundation of Australia (Special Grant in Burkitt Lymphoma), the Victorian Cancer Agency (Mid-Career Fellowship MCRF17028), and a PhD fellowship from Melbourne University. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS.