Journal article
Clarifying the role of EMSY in DNA repair in ovarian cancer
O Kondrashova, CL Scott
Cancer | WILEY | Published : 2019
DOI: 10.1002/cncr.32135
Abstract
Although evidence supports the involvement of EMSY in DNA repair, EMSY amplification fails to suppress RAD51 foci formation, a marker of homologous recombination DNA repair. The majority of analyses to date have been performed in cell lines. Models more closely representing patients should be studied to determine the relevance of EMSY for use as a predictive biomarker for response to platinum and poly (adenosine diphosphate ribose) polymerase inhibitor therapy.
Grants
Awarded by Victorian Cancer Agency
Funding Acknowledgements
Supported by the Australian National Health and Medical Research Council (project grant 1062702 to Clare L. Scott), the Stafford Fox Medical Research Foundation (to Clare L. Scott), Cancer Council Victoria (Sir Edward Dunlop Fellowship in Cancer Research to Clare L. Scott), and the Victorian Cancer Agency (clinical fellowships CRF10-20 and CRF16014 to Clare L. Scott). This work was made possible through the Australian Cancer Research Foundation, the Victorian State Government Operational Infrastructure Support, and Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme.