Journal article

Template-Free Synthesis of Chemically Asymmetric Silica Nanotubes for Selective Cargo Loading and Sustained Drug Release

Chao Deng, Qian Zhang, Cong Fu, Fangzhou Zhou, Wuli Yang, Deliang Yi, Xingdong Wang, Yi Tang, Frank Caruso, Yajun Wang

CHEMISTRY OF MATERIALS | AMER CHEMICAL SOC | Published : 2019

Abstract

SiO2 nanotubes (NTs), with uniform diameter (∼25 nm) and tailored shell thickness (1–5 nm), and featuring chemically asymmetric surfaces (a silane-functionalized exterior surface and a negatively charged (−Si–O–) interior surface) are prepared by a facile, template-free approach. Owing to their chemically asymmetric properties, positively charged cargoes can be selectively loaded with high content into the SiO2 NTs via electrostatic interaction. Mediated by polyamidoamine dendrimers preassembled in the NTs, different noble metal nanoparticles can be selectively deposited inside the NTs with high density and uniform size. Owing to their high specific surface area and elongated pore structure ..

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University of Melbourne Researchers

Grants

Awarded by National Key R&D Program of China


Awarded by National Natural Science Foundation of China


Awarded by Science & Technology Commission of Shanghai Municipality


Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by NHMRC Senior Principal Research Fellowship


Funding Acknowledgements

This work was financially supported by the National Key R&D Program of China (2018YFC1602301, 2018YFA0209402), the National Natural Science Foundation of China (21373059), and the Science & Technology Commission of Shanghai Municipality (16DZ2270100). This work was also supported by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (CE140100036). F.C. acknowledges the award of an NHMRC Senior Principal Research Fellowship (GNT1135806). Y.W. acknowledges support from the National 1000 Youth Talents Program of China.