Parallel worlds of the adaptive and innate immune cell networks
Qiutong Huang, Gabrielle T Belz
CURRENT OPINION IN IMMUNOLOGY | CURRENT BIOLOGY LTD | Published : 2019
Adaptive and innate immune cells have typically been functionally and temporally segregated even though they share a number of salient features. Over the past decade, significant advances have been made in understanding the composition and diversity of both innate and adaptive cell populations. This has shed light on how cells from two distinct pathways are so highly complementary. Innate lymphoid cells (ILCs) are pivotally positioned in tissues to form a stable population akin to tissue-resident T cells that protects the body. Nevertheless, the pathway by which different lymphocytes enter tissues, terminally differentiate and are replenished to maintain populations remains incompletely unde..View full abstract
We thank Dr Nicolas Jacquelot for critical reading of the manuscript and helpful suggestions. This work was supported by grants and fellowships from the National Health and Medical Research Council of Australia (GTB), an Australian Government Research Training Program Scholarship (Q.H), The Rebecca L. Cooper Foundation Medical Research Foundation and the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support Schemes (Walter and Eliza Hall Institute of Medical Research).