Journal article

New players in the gene regulatory network controlling late B cell differentiation

Simon N Willis, Stephen L Nutt

CURRENT OPINION IN IMMUNOLOGY | CURRENT BIOLOGY LTD | Published : 2019

Abstract

The differentiation of B cells into antibody-secreting plasma cells is associated with profound changes in morphology, lifespan, and cellular metabolism that are needed to support high rates of antibody production. These processes are driven by dramatic alterations to the transcriptional program and to the organization of the nucleus itself that in turn are regulated by the activity of a select group of transcription factors and epigenetic regulators. Although the core differentiation program is conserved in all mature B cells, subset-specific regulators, such as those found in B1 or memory B cells, provide additional complexity. Here, we review the key components of the gene regulatory netw..

View full abstract

Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by Cancer Council Victoria


Funding Acknowledgements

This work was supported by grants from the National Health and Medical Research Council (NHMRC) of Australia (1054925, 1058238 and 1144905) and the Cancer Council Victoria (1102662) to S.L.N. S.N.W was supported by a Walter and Eliza Hall Trust Centenary Fellowship. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRHS.