Journal article

Intranasal oxytocin alters amygdala-temporal resting-state functional connectivity in body dysmorphic disorder: A double-blind placebo-controlled randomized trial

Sally A Grace, Izelle Labuschagne, David J Castle, Susan L Rossell

Psychoneuroendocrinology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019


The aetiology of body dysmorphic disorder (BDD) is poorly understood. Recent evidence from functional brain imaging studies suggests that BDD is associated with aberrant task-based functional connectivity and that intranasal oxytocin (OXT) may improve network connectivity in BDD patients. Thus, the aim of this study was to investigate the effect of intranasal OXT on amygdala resting-state functional connectivity (rsFC) in BDD. In a randomized, double-blind, cross-over design, 19 BDD participants and 17 demographically matched healthy control participants received intranasal OXT (24 IU) or placebo prior to resting-state functional magnetic resonance imaging. The left and right amygdala were s..

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University of Melbourne Researchers


Awarded by BDBSF Project

Awarded by ACURF Program

Funding Acknowledgements

SG was supported by an Australian Government Research Training Program Scholarship. SG and SR are investigators on a project examining oxytocin on functional brain activity in body dysmorphic disorder (BDBSF Project Grant 4000000098). SG and IL are investigators on a project examining the impact of oxytocin administration on social cognition and neural activity in ageing (ACURF Program Grant 20130000557). The authors would like to acknowledge the flagship funding provided to the Swinburne Neuroimaging Facility from the National Imaging Facility (NIF) under the National Collaborative Researcher Infrastructure Strategy (NCRIS) implemented by the Australian Government.