Journal article
Threshold of Pulmonary Hypertension Associated With Increased Mortality
G Strange, S Stewart, DS Celermajer, D Prior, GM Scalia, TH Marwick, E Gabbay, M Ilton, M Joseph, J Codde, D Playford
Journal of the American College of Cardiology | ELSEVIER SCIENCE INC | Published : 2019
Abstract
Background: There is increasing evidence that current thresholds for diagnosing pulmonary hypertension (PHT) underestimate the prognostic impact of PHT. Objectives: The aim of this study was to determine the prognostic impact of increasing pulmonary pressures within the National Echocardiography Database of Australia cohort (n = 313,492). Methods: The distribution of estimated right ventricular systolic pressure (eRVSP) was examined in 157,842 men and women. All had data linkage to long-term survival during median follow-up of 4.2 years (interquartile range: 2.2 to 7.5 years). Results: The cohort comprised 74,405 men and 83,437 women 65.6 ± 17.7 years of age. Overall, 17,955 (11.4%), 7,016 (..
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Awarded by National Health and Medical Research of Australia
Funding Acknowledgements
The National Echo Database Australia was initially supported (database engineering and infrastructure costs) through unrestricted research grants from Actelion, Bayer, and GlaxoSmithKline. It is also supported by National Health and Medical Research of Australia funding (grant 1055214). Dr. Celermajer works at an institution that has received clinical trials funding and educational grants from Actelion. Dr. Prior has received payments for talks from Actelion. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Bradley A. Maron, MD, served as Guest Associate Editor for this paper.