Journal article
Gut Microbiota Changes in Patients with Bipolar Depression
S Hu, A Li, T Huang, J Lai, J Li, ME Sublette, H Lu, Q Lu, Y Du, Z Hu, CH Ng, H Zhang, J Lu, T Mou, S Lu, D Wang, J Duan, J Hu, M Huang, N Wei Show all
Advanced Science | WILEY | Published : 2019
Open access
Abstract
This study aims to characterize the gut microbiota in depressed patients with bipolar disorder (BD) compared with healthy controls (HCs), to examine the effects of quetiapine treatment on the microbiota, and to explore the potential of microbiota as a biomarker for BD diagnosis and treatment outcome. Analysis of 16S-ribosomal RNA gene sequences reveals that gut microbial composition and diversity are significantly different between BD patients and HCs. Phylum Bacteroidetes and Firmicutes are the predominant bacterial communities in BD patients and HCs, respectively. Lower levels of butyrate-producing bacteria are observed in untreated patients. Microbial composition changes following quetiap..
View full abstractGrants
Awarded by National Natural Science Foundation of China
Funding Acknowledgements
S.-H.H. and A.L. contributed equally to this work. This study was funded in part by grants from the National Key Research and Development Program of China (No. 2016YFC1307104 to S.H.H.), the Key Research Project of Zhejiang Province (No. 2015C03040 to Y.X.), the China Precision Medicine Initiative (No. 2016YFC0906300 to M.D.L.), and the National Natural Science Foundation of China (No. 81371493 to S.H.).