A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer
Roxanne Toivanen, Luc Furic
JOURNAL OF CELL BIOLOGY | ROCKEFELLER UNIV PRESS | Published : 2019
PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC stability.
Awarded by Department of Health and Human Services through the Victorian Cancer Agency
We acknowledge funding from the Department of Health and Human Services acting through the Victorian Cancer Agency (MCRF16007 to L. Furic and MCRF18012 to R. Toivanen).