Journal article

Blunted diuretic and natriuretic responses to acute sodium loading early after catheter-based renal denervation in normotensive sheep

Zoe McArdle, Roberto B Pontes, Song T Yao, Yugeh R Lankadeva, Reetu R Singh, Sally G Hood, Markus P Schlaich, Clive N May, Lindsea C Booth

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology | AMER PHYSIOLOGICAL SOC | Published : 2019

Abstract

Catheter-based renal denervation (RDN) was introduced as a treatment for resistant hypertension. There remain critical questions regarding the physiological mechanisms underlying the hypotensive effects of catheter-based RDN. Previous studies indicate that surgical denervation reduces renin and the natriuretic response to saline loading; however, the effects on these variables of catheter-based RDN, which does not yield complete denervation, are largely unknown. The aim of this study was to investigate the effects of catheter-based RDN on glomerular-associated renin and regulation of fluid and sodium homeostasis in response to physiological challenges. First, immunohistochemical staining for..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by NHMRC


Awarded by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Capes)


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (NHMRC) (1012100) and the Victorian Government's Operational Infrastructure Support Program. L. C. Booth was the recipient of a NHMRC Early Career Fellowship (1054619), and R. B. Pontes was supported by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Capes; 99999.007332/2015-07 BEX). C. N. May and M. P. Schlaich were supported by NHMRC Research Fellowships.