Evidence for type-specific DNA methylation patterns in epilepsy: a discordant monozygotic twin approach
Namitha Mohandas, Yuk Jing Loke, Stephanie Hopkins, Lisa Mackenzie, Carmen Bennett, Samuel F Berkovic, Lata Vadlamudi, Jeffrey M Craig
Epigenomics | FUTURE MEDICINE LTD | Published : 2019
Aim: Epilepsy is a common neurological disorder characterized by recurrent seizures. We performed epigenetic analyses between and within 15 monozygotic (MZ) twin pairs discordant for focal or generalized epilepsy. Methods: DNA methylation analysis was performed using Illumina Infinium MethylationEPIC arrays, in blood and buccal samples. Results: Differentially methylated regions between epilepsy types associated with PM20D1 and GFPT2 genes in both tissues. Within MZ discordant twin pairs, differentially methylated regions associated with OTX1 and ARID5B genes for generalized epilepsy and TTC39C and DLX5 genes for focal epilepsy. Conclusion: This is the first epigenome-wide association study,..View full abstract
Awarded by Financial Markets Foundation for Children
This work was supported by grant from the Financial Markets Foundation for Children (grant number 2013-207). L Vadlamudi was supported by a Queensland Health Research Fellowship. This work was also supported by The University of Queensland Mayne Bequest Funds, Royal Brisbane and Women's Foundation Grant, Viertal-Charitable Foundation, Ramaciotti Establishment Grant and The Servier Barry Young Fellowship in Neurology.The authors have no other relevant affiliations or financialinvolvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.